What is the primary mechanism by which hepcidin regulates iron homeostasis in the body, particularly in the context of anemia of chronic disease?

A By increasing the expression of ferroportin
B By decreasing the absorption of dietary iron
C By binding to and inhibiting the function of ferroportin ✓
D By stimulating the release of iron from macrophages

Explanation

Hepcidin plays a crucial role in iron homeostasis by binding to and inhibiting the function of ferroportin, which is the only known iron export channel. This action reduces iron export from cells and leads to decreased plasma iron levels, contributing to anemia in chronic diseases.

Source

Journal of Clinical Investigation
Hematology Hematology: Anemia Hematology: Anemia Hard MEDICAL Confidence: high