Which of the following anemias is characterized by a defect in the glucose-6-phosphate dehydrogenase (G6PD) enzyme, leading to increased susceptibility to oxidative stress?

A Sickle cell anemia
B Thalassemia major
C Glucose-6-phosphate dehydrogenase deficiency anemia ✓
D Hereditary spherocytosis

Explanation

G6PD deficiency is a genetic disorder that affects the G6PD enzyme, leading to increased susceptibility to oxidative stress and resulting in hemolytic anemia.

Source

Robbins and Cotran Pathologic Basis of Disease
Hematology Hematology: Anemia Hematology: Anemia Easy MEDICAL Confidence: high