Which of the following types of anemia is associated with an increased risk of developing thrombosis due to an imbalance in the ratio of globin chains?

A Sickle cell anemia
B Thalassemia major
C Thalassemia intermedia ✓
D Beta-thalassemia trait with high hemoglobin F levels

Explanation

Thalassemia intermedia is associated with an increased risk of thrombosis due to an imbalance in the ratio of globin chains, leading to increased red blood cell adhesion and activation of coagulation pathways.

Source

European Journal of Haematology
Hematology Hematology: Anemia Hematology: Anemia Hard MEDICAL Confidence: medium