Which of the following anemias is characterized by a defect in the production of adenosine triphosphate (ATP) in red blood cells?

A Pyruvate kinase deficiency anemia ✓
B Glucose-6-phosphate dehydrogenase deficiency anemia
C Sickle cell anemia
D Thalassemia major

Explanation

Pyruvate kinase deficiency anemia is a rare genetic disorder characterized by a defect in the production of ATP in red blood cells, leading to hemolytic anemia.

Source

Wintrobe's Clinical Hematology
Hematology Hematology: Anemia Hematology: Anemia Hard MEDICAL Confidence: high