Which of the following cellular processes is impaired in Shwachman-Diamond syndrome, a disorder characterized by bone marrow failure?

A Ribosome biogenesis ✓
B Mitochondrial biogenesis
C Lysosome biogenesis
D Proteasome biogenesis

Explanation

Shwachman-Diamond syndrome is a rare genetic disorder characterized by bone marrow failure, pancreatic insufficiency, and skeletal abnormalities. The disease is caused by mutations in the SBDS gene, which is involved in ribosome biogenesis.

Source

Nature Genetics journal
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Hard MEDICAL Confidence: high