What is the primary mechanism by which 2,3-Bisphosphoglycerate (2,3-BPG) regulates oxygen binding to hemoglobin?

A Increasing the affinity of hemoglobin for oxygen
B Decreasing the affinity of hemoglobin for oxygen ✓
C Stabilizing the tetrameric structure of hemoglobin
D Enhancing the cooperativity of oxygen binding

Explanation

2,3-Bisphosphoglycerate (2,3-BPG) is a molecule that binds to hemoglobin and decreases its affinity for oxygen, facilitating the release of oxygen to tissues.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Medium MEDICAL Confidence: high