What is the primary mechanism by which enzyme deficiencies lead to lysosomal storage diseases?

A Accumulation of toxic metabolites ✓
B Impaired protein synthesis
C Disrupted cellular transport
D Enhanced enzymatic activity

Explanation

Lysosomal storage diseases result from the accumulation of toxic metabolites due to enzyme deficiencies, leading to cellular dysfunction.

Source

Medical Biochemistry textbook
Enzymes in Disease Biochemistry Lysosomal Storage Diseases Medium MEDICAL Confidence: high