Which enzyme's abnormal activity is associated with the development of Gaucher's disease, a genetic disorder characterized by the accumulation of glucocerebroside in cells and certain organs?

Gaucher's disease is caused by a deficiency or abnormal activity of the enzyme Glucocerebrosidase, which is responsible for breaking down glucocerebroside into glucose and ceramide. Accumulation of glucocerebroside leads to the characteristic symptoms of Gaucher's disease.