A patient with severe vomiting presents with hypochloremic metabolic alkalosis. What is the most likely cause of this condition?

A Loss of hydrogen ions due to gastric acid secretion
B Excessive bicarbonate administration
C Chloride-rich fluid loss from the gastrointestinal tract ✓
D Renal compensation for respiratory acidosis

Explanation

Hypochloremic metabolic alkalosis is often caused by the loss of chloride-rich fluids, such as gastric contents during severe vomiting. This leads to a decrease in chloride ions, which in turn increases bicarbonate levels, resulting in metabolic alkalosis.

Source

Harrison's Principles of Internal Medicine
Electrolytes and Acid-Base Balance Pathophysiology Acid-Base Disorders Hard MEDICAL Confidence: high