What is the primary mechanism by which the enzyme glucocerebrosidase contributes to the development of Gaucher's disease?

A Inhibition of lysosomal function
B Deficiency of enzyme activity leading to accumulation of glucocerebroside ✓
C Overproduction of glucocerebroside
D Enhanced degradation of glucocerebroside

Explanation

Gaucher's disease is caused by a deficiency in the enzyme glucocerebrosidase, leading to the accumulation of glucocerebroside within cells.

Source

NCERT Class 12 Biochemistry
Enzymes in Disease Biochemistry Lysosomal Storage Diseases Medium MEDICAL Confidence: high