Which enzyme plays a crucial role in the pathogenesis of gout by catalyzing the conversion of hypoxanthine to xanthine and subsequently to uric acid?

A Xanthine oxidase ✓
B Uricase
C Glutathione peroxidase
D Superoxide dismutase

Explanation

Xanthine oxidase is an enzyme responsible for the conversion of hypoxanthine to xanthine and then to uric acid, which accumulates in gout.

Source

Harper's Biochemistry
Enzymes in Disease Biochemistry Purine Metabolism Disorders Hard MEDICAL Confidence: high