What is the primary enzyme responsible for the breakdown of glycogen to glucose in the liver, and its deficiency leads to a glycogen storage disease?

A Glucose-6-phosphatase
B Debranching enzyme
C Phosphorylase ✓
D Amylase

Explanation

Phosphorylase is the primary enzyme responsible for breaking down glycogen to glucose in the liver. Its deficiency leads to Hers' disease, a type of glycogen storage disease.

Source

Harper's Biochemistry
Enzymes in Disease Biochemistry Glycogen Metabolism Medium MEDICAL Confidence: high