Which vitamin acts as a coenzyme for the enzyme pyruvate dehydrogenase, facilitating the conversion of pyruvate to acetyl-CoA?

A Thiamine (Vitamin B1) ✓
B Riboflavin (Vitamin B2)
C Niacin (Vitamin B3)
D Pantothenic acid (Vitamin B5)

Explanation

Thiamine, in its active form thiamine pyrophosphate (TPP), serves as a coenzyme for pyruvate dehydrogenase, an enzyme critical for the conversion of pyruvate into acetyl-CoA, a key step in cellular respiration.

Source

Lehninger Principles of Biochemistry
Vitamins Biochemistry Water-Soluble Vitamins Medium MEDICAL Confidence: high