Which of the following types of ubiquitin ligases is responsible for targeting misfolded proteins for degradation by the proteasome?

A SCF complex
B Anaphase-promoting complex
C E3 ubiquitin ligase, such as Parkin or CHIP ✓
D Ubiquitin-activating enzyme

Explanation

E3 ubiquitin ligases, such as Parkin or CHIP, are responsible for recognizing and targeting misfolded proteins for degradation by the proteasome, thereby maintaining protein homeostasis.

Source

Harper et al., Cell Biology, 2nd edition
Protein Metabolism Cell Biology Protein Degradation Hard MEDICAL Confidence: high