Which of the following types of ubiquitin ligases is involved in the regulation of protein degradation in response to cellular stress?

A Homologous to E6-AP C-terminus (HECT) domain ligases
B U-box ligases
C RING finger ligases
D All of the above ✓

Explanation

All three types of ubiquitin ligases, including HECT domain ligases, U-box ligases, and RING finger ligases, can be involved in the regulation of protein degradation in response to cellular stress.

Source

Harper et al., The Ubiquitin-Proteasome Pathway
Protein Metabolism Cell Biology Protein Degradation Medium MEDICAL Confidence: high