Which of the following types of protein degradation is mediated by the N-end rule pathway?

A Lysosomal degradation
B Proteasomal degradation
C Calpain-mediated degradation
D Degradation of proteins with destabilizing N-terminal residues ✓

Explanation

The N-end rule pathway is a type of protein degradation that targets proteins with destabilizing N-terminal residues, such as arginine, lysine, and leucine.

Source

Varshavsky, The N-end rule pathway of protein degradation
Protein Metabolism Biochemistry Protein Degradation Medium NURSING Confidence: high