Which of the following types of protein degradation is mediated by the ubiquitin-proteasome pathway and involves the recognition of misfolded or damaged proteins?

A Autophagy
B Proteolysis
C Apoptosis
D ER-associated degradation (ERAD) ✓

Explanation

The ubiquitin-proteasome pathway is a key mechanism for degrading misfolded or damaged proteins, and ERAD is a specific type of protein degradation that involves the recognition and targeting of misfolded proteins in the endoplasmic reticulum for degradation by the proteasome.

Source

Kirschner et al. (2019) - Cell Biology: A Short Course
Protein Metabolism Cell Biology Protein Degradation Hard MEDICAL Confidence: high