Which of the following types of protein degradation is characterized by the cleavage of proteins into smaller peptides by lysosomal enzymes?

A Ubiquitin-proteasome pathway
B Autophagy
C Lysosomal degradation ✓
D Proteolytic degradation by calpains

Explanation

Lysosomal degradation involves the cleavage of proteins into smaller peptides by lysosomal enzymes, such as cathepsins, which are active at acidic pH.

Source

Lodish et al., Molecular Cell Biology
Protein Metabolism Cell Biology Protein Degradation Hard MEDICAL Confidence: high