Which of the following types of anemia is characterized by a defect in the synthesis of the glycosylphosphatidylinositol (GPI) anchor, leading to paroxysmal nocturnal hemoglobinuria?

A Sickle cell anemia
B Thalassemia major
C Hereditary spherocytosis
D Paroxysmal nocturnal hemoglobinuria ✓

Explanation

Paroxysmal nocturnal hemoglobinuria is a rare type of anemia characterized by a defect in the synthesis of the GPI anchor, leading to the premature destruction of red blood cells.

Source

UpToDate
Hematology Hematology: Anemia Hematology: Anemia Hard MEDICAL Confidence: high