Which of the following types of anemia is characterized by a defect in the synthesis of globin chains, leading to the accumulation of alpha-globin chains in the red blood cells?

A Beta-thalassemia major
B Alpha-thalassemia major ✓
C Hemoglobin H disease
D Sickle cell disease

Explanation

Alpha-thalassemia major is a type of anemia characterized by a defect in the synthesis of alpha-globin chains, leading to the accumulation of alpha-globin chains in the red blood cells.

Source

Robbins and Cotran Pathologic Basis of Disease
Hematology Hematology: Anemia Hematology: Anemia Medium MEDICAL Confidence: high