Which of the following transcription factors plays a crucial role in the specification of megakaryocyte lineage from hematopoietic progenitor cells?

A GATA1 ✓
B PU.1
C C/EBPα
D NF-κB

Explanation

GATA1 is a transcription factor essential for the development and maturation of megakaryocytes, and its deficiency leads to thrombocytopenia and megakaryocytic dysplasia.

Source

Nature journal
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Hard MEDICAL Confidence: high