Which of the following transcription factors is essential for the specification of hematopoietic stem cells from mesodermal progenitors during embryonic development?

A GATA1
B GATA2
C SCL/TAL1 ✓
D RUNX1

Explanation

SCL/TAL1 is a transcription factor that plays a critical role in the specification of hematopoietic stem cells from mesodermal progenitors during embryonic development. It regulates the expression of genes involved in hematopoiesis and is essential for the formation of hematopoietic stem cells.

Source

Nature Reviews Immunology
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Hard MEDICAL Confidence: high