Which of the following transcription factors is essential for the development of hematopoietic stem cells in the yolk sac?

A GATA-1
B GATA-2
C SCL/TAL1 ✓
D PU.1

Explanation

SCL/TAL1 is a transcription factor that plays a critical role in the development of hematopoietic stem cells in the yolk sac, and its deficiency leads to embryonic lethality due to a lack of hematopoiesis.

Source

Nature Reviews Immunology
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Hard MEDICAL Confidence: high