Which of the following statements is true regarding the use of activated protein C in the treatment of severe sepsis?

A It is used to treat bleeding complications in sepsis
B It is used to reduce the risk of thrombosis in sepsis
C It is used to reduce mortality in severe sepsis by inhibiting coagulation and inflammation ✓
D It is used to treat anemia in sepsis

Explanation

Activated protein C, also known as drotrecogin alfa, was used to reduce mortality in severe sepsis by inhibiting coagulation and inflammation, although its use has been discontinued due to lack of efficacy and safety concerns.

Source

NEJM, 2001; 345:699-709
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Medium MEDICAL Confidence: medium