Which of the following statements accurately describes the effect of 2,3-Bisphosphoglycerate (2,3-BPG) on hemoglobin's oxygen binding properties?

A 2,3-BPG increases hemoglobin's affinity for oxygen
B 2,3-BPG decreases hemoglobin's affinity for oxygen ✓
C 2,3-BPG has no effect on hemoglobin's affinity for oxygen
D 2,3-BPG increases the cooperativity of oxygen binding to hemoglobin

Explanation

2,3-Bisphosphoglycerate (2,3-BPG) is an allosteric effector that binds to hemoglobin and decreases its affinity for oxygen. This effect is crucial for adapting to high altitudes or conditions of low oxygen availability, as it facilitates the release of oxygen from hemoglobin to tissues.

Source

Berne and Levy Physiology
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Hard MEDICAL Confidence: high