Which of the following proteins plays a crucial role in the regulation of protein synthesis by binding to the mRNA cap and preventing translation initiation?

A eIF4E
B eIF4G
C 4E-BP1 ✓
D PABP

Explanation

4E-BP1 (eIF4E-binding protein 1) binds to the mRNA cap-binding protein eIF4E, preventing it from interacting with other initiation factors and thus inhibiting translation initiation.

Source

Cell Biology by Alberts et al.
Protein Metabolism Molecular Biology Translation Regulation Hard MEDICAL Confidence: high