Which of the following proteins plays a crucial role in the regulation of hematopoietic stem cell self-renewal and is often referred to as a 'stemness' gene?

A BCL-2
B BMI-1 ✓
C PTEN
D TP53

Explanation

BMI-1 is a polycomb ring finger protein that plays a crucial role in the regulation of hematopoietic stem cell self-renewal.

Source

Nature Reviews Cancer
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Medium MEDICAL Confidence: high