Which of the following proteins plays a crucial role in the quality control of protein folding in the endoplasmic reticulum?

A Hsp60
B Hsp70
C BiP (Binding Immunoglobulin Protein) ✓
D Protein Disulfide Isomerase (PDI)

Explanation

BiP is a molecular chaperone that plays a critical role in the quality control of protein folding in the endoplasmic reticulum, ensuring that only properly folded proteins are secreted or transported to other cellular compartments.

Mnemonic

BiP = 'binding' immunoglobulin protein, 'binding' to misfolded proteins

Source

Lodish et al., Molecular Cell Biology
Protein Metabolism Cell Biology Protein Quality Control Hard MEDICAL Confidence: medium