Which of the following pathways is responsible for the degradation of aberrant proteins that are retained in the endoplasmic reticulum?

A Ubiquitin-proteasome pathway
B Lysosomal pathway
C Endoplasmic reticulum-associated degradation (ERAD) pathway ✓
D Autophagy-lysosomal pathway

Explanation

The ERAD pathway is responsible for the degradation of aberrant proteins that are retained in the endoplasmic reticulum, which helps to maintain protein homeostasis and prevent protein aggregation diseases.

Source

Somesh et al. Cellular and Molecular Life Sciences
Protein Metabolism Cell Biology Protein Quality Control Medium MEDICAL Confidence: high