Which of the following metabolic disorders is characterized by an accumulation of very-long-chain fatty acids in the brain and adrenal glands?

A Gaucher's disease
B Niemann-Pick disease
C Adrenoleukodystrophy ✓
D Tay-Sachs disease

Explanation

Adrenoleukodystrophy is a genetic disorder that affects the breakdown of very-long-chain fatty acids, leading to their accumulation in the brain and adrenal glands.

Mnemonic

ALD = Accumulation Leads to Damage

Source

Scriver's The Metabolic and Molecular Bases of Inherited Disease
Metabolic and Nutritional Disorders Lipid Metabolism Fatty Acid Disorders Hard NURSING Confidence: high