Which of the following is a key regulator of the transcription of genes involved in fatty acid synthesis?

A Sterol regulatory element-binding protein (SREBP)
B Carbohydrate-responsive element-binding protein (ChREBP) ✓
C Fatty acid synthase
D Acetyl-CoA carboxylase

Explanation

Carbohydrate-responsive element-binding protein (ChREBP) is a transcription factor that regulates the expression of genes involved in fatty acid synthesis in response to glucose availability.

Mnemonic

ChREBP = 'chair' that regulates fatty acid synthesis

Source

Journal of Biological Chemistry
Lipid Metabolism Molecular Biology Transcriptional Regulation of Lipid Metabolism Hard MEDICAL Confidence: medium