Which of the following is a function of the niche in hematopoietic stem cell regulation?

A To promote differentiation into all blood cell types
B To suppress self-renewal and maintain quiescence ✓
C To increase proliferation and reduce apoptosis
D To reduce adhesion to the bone marrow microenvironment

Explanation

The niche plays a critical role in regulating hematopoietic stem cells by maintaining their quiescence and suppressing self-renewal, thus preserving their long-term repopulating ability.

Mnemonic

Niche Balances Stem Cell Behavior

Source

Nature Reviews Immunology
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Medium MEDICAL Confidence: high