Which of the following is a characteristic feature of hereditary spherocytosis, a congenital anemia?

A Presence of schistocytes
B Increased osmotic fragility of red blood cells ✓
C Reduced expression of glycophorin A
D Elevated levels of lactate dehydrogenase

Explanation

Hereditary spherocytosis is characterized by the production of red blood cells that are sphere-shaped rather than the normal biconcave disk shape, leading to increased osmotic fragility and premature destruction.

Source

Orphanet Journal of Rare Diseases
Hematology Hematology: Anemia Hematology: Anemia Hard MEDICAL Confidence: high