Which of the following hemoglobin variants is associated with increased susceptibility to sickling and hemolysis?

A Hemoglobin C
B Hemoglobin E
C Hemoglobin S ✓
D Hemoglobin F

Explanation

Hemoglobin S is the abnormal hemoglobin variant responsible for sickle cell disease, characterized by increased susceptibility to sickling and hemolysis.

Source

Robbins and Cotran Pathologic Basis of Disease
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Easy MEDICAL Confidence: high