Which of the following hematopoietic lineage commitment processes involves the suppression of the PU.1 transcription factor?

A Commitment to the erythroid lineage ✓
B Commitment to the megakaryocytic lineage
C Commitment to the granulocytic lineage
D Commitment to the lymphoid lineage

Explanation

The suppression of PU.1 is necessary for commitment to the erythroid lineage, as it allows for the expression of erythroid-specific genes.

Source

Molecular Cell Biology by Lodish et al.
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Hard MEDICAL Confidence: medium