Which of the following genes is involved in the regulation of hematopoietic stem cell self-renewal and is often mutated in myeloid leukemias?

A RUNX1 ✓

B GATA1

C TP53

D MLL1

Explanation

The RUNX1 gene is involved in the regulation of hematopoietic stem cell self-renewal and is often mutated in myeloid leukemias, including acute myeloid leukemia (AML).

Source

Liu et al. (2015) Nature Reviews Cancer

Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Hard MEDICAL Confidence: high

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Which of the following genes is involved in the regulation of hematopoietic stem cell self-renewal and is often mutated in myeloid leukemias?

Explanation

Source

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