Which of the following genes is involved in the regulation of hematopoietic stem cell self-renewal and is often mutated in myelodysplastic syndromes?

A TP53

B ASXL1

C DNMT3A ✓

D TET2

Explanation

Mutations in the DNMT3A gene have been implicated in the regulation of hematopoietic stem cell self-renewal and are often found in myelodysplastic syndromes.

Source

New England Journal of Medicine

Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Medium MEDICAL Confidence: high

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Which of the following genes is involved in the regulation of hematopoietic stem cell self-renewal and is often mutated in myelodysplastic syndromes?

Explanation

Source

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