Which of the following factors influences the binding of oxygen to hemoglobin in a way that is opposite to the effect of an increase in CO2 concentration?
Explanation
An increase in pH (decrease in hydrogen ion concentration) increases the affinity of hemoglobin for oxygen, which is opposite to the effect of an increase in CO2 concentration, which decreases the affinity of hemoglobin for oxygen.
Source
Berne and Levy Physiology