Which of the following enzymes plays a crucial role in the regulation of heme synthesis during erythropoiesis?

A Delta-aminolevulinic acid synthase ✓
B Ferrochelatase
C Porphobilinogen deaminase
D Uroporphyrinogen decarboxylase

Explanation

Delta-aminolevulinic acid synthase is the first and rate-limiting enzyme in the heme biosynthetic pathway, and its activity is tightly regulated during erythropoiesis to ensure proper heme synthesis.

Source

Lippincott's Biochemistry (2018)
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Hard MEDICAL Confidence: high