Which of the following enzymes is responsible for the degradation of abnormal or misfolded proteins in the endoplasmic reticulum?

A Proteasome
B Calpain
C Caspase
D ER-associated degradation (ERAD) enzyme, EDEM1
ER-associated degradation (ERAD) is a quality control process that degrades abnormal or misfolded proteins in the endoplasmic reticulum, and EDEM1 is an enzyme involved in this process.
Kaufman et al., Trends in Cell Biology
Protein Metabolism Cell Biology Protein Quality Control Hard MEDICAL Confidence: medium