Which of the following enzymes is responsible for the conversion of delta-aminolevulinic acid to porphobilinogen in the biosynthesis of heme, and its deficiency can lead to a specific type of anemia?

A Aminolevulinate dehydratase ✓
B Porphobilinogen synthase
C Uroporphyrinogen decarboxylase
D Ferrochelatase

Explanation

Aminolevulinate dehydratase is an enzyme involved in the biosynthesis of heme, and its deficiency can lead to a specific type of anemia known as X-linked sideroblastic anemia.

Source

Orphanet Journal of Rare Diseases
Hematology Hematology: Anemia Hematology: Anemia Hard MEDICAL Confidence: high