Which of the following diseases is characterized by an accumulation of alpha-synuclein due to a deficiency in the enzyme glucocerebrosidase?

A Parkinson's disease ✓
B Alzheimer's disease
C Huntington's disease
D Gaucher's disease

Explanation

A deficiency in glucocerebrosidase has been linked to an increased risk of Parkinson's disease, which is characterized by the accumulation of alpha-synuclein.

Source

_Science - Glucocerebrosidase and Parkinson's disease_
Enzymes in Disease Molecular Biology Neurodegenerative Diseases Hard MEDICAL Confidence: medium