Which of the following coagulation disorders is characterized by an autosomal dominant inheritance pattern and is caused by a mutation in the gene encoding the protein C receptor, endothelial protein C receptor (EPCR)?

A Protein C deficiency
B Protein S deficiency
C Factor V Leiden thrombophilia ✓
D Antithrombin III deficiency

Explanation

Factor V Leiden thrombophilia is an autosomal dominant disorder caused by a mutation in the gene encoding the protein C receptor, endothelial protein C receptor (EPCR), leading to increased risk of venous thrombosis.

Mnemonic

Factor V = Five, like the fifth component of the coagulation cascade

Source

Harrison's Principles of Internal Medicine
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: high