Which of the following coagulation disorders is characterized by an abnormality in the fibrinolytic pathway?

A Hemophilia A
B Factor VII deficiency
C Plasminogen activator inhibitor-1 (PAI-1) deficiency ✓
D Prothrombin deficiency

Explanation

PAI-1 deficiency is a rare coagulation disorder characterized by an abnormality in the fibrinolytic pathway, leading to increased fibrinolysis and a bleeding tendency.

Mnemonic

PAI-1 = Plasmin's Arch Enemy

Source

Williams Hematology
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: medium