Which of the following coagulation disorders is characterized by a mutation in the gene encoding the anticoagulant protein C?

A Protein S deficiency
B Antithrombin III deficiency
C Factor V Leiden thrombophilia ✓
D Prothrombin G20210A mutation

Explanation

Factor V Leiden thrombophilia is caused by a mutation in the gene encoding factor V, which leads to resistance to activated protein C, a key anticoagulant protein. This results in an increased risk of venous thromboembolism.

Source

Harrison's Principles of Internal Medicine
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: high