Which of the following coagulation disorders is associated with an increased risk of thrombosis due to a deficiency of protein C?

A Protein S deficiency
B Antithrombin III deficiency
C Factor V Leiden thrombophilia ✓
D Homocystinuria

Explanation

Factor V Leiden thrombophilia is a genetic disorder that increases the risk of thrombosis due to a mutation in the factor V gene, which makes it resistant to inactivation by protein C.

Source

Harrison's Principles of Internal Medicine
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: high