Which of the following coagulation disorders is associated with a deficiency of the enzyme ADAMTS13, leading to an increased risk of thrombotic thrombocytopenic purpura?

A Von Willebrand disease
B Hemophilia A
C Thrombotic thrombocytopenic purpura ✓
D Disseminated intravascular coagulation

Explanation

Thrombotic thrombocytopenic purpura is a rare blood disorder characterized by a deficiency of the enzyme ADAMTS13, which leads to an increased risk of blood clots.

Source

New England Journal of Medicine
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: high