Which of the following blood group systems is responsible for the most severe hemolytic transfusion reactions?

A Kell blood group system
B Duffy blood group system
C ABO blood group system ✓
D MNS blood group system

Explanation

The ABO blood group system is responsible for the most severe hemolytic transfusion reactions due to the presence of pre-formed antibodies against A or B antigens.

Source

Williams Hematology
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Easy MEDICAL PYQ 2019 2019 Confidence: high