Which of the following blood group systems is associated with an increased risk of hemolytic disease of the newborn (HDN) due to anti-U antibodies?

A Rh blood group system
B Kell blood group system
C MNS blood group system
D Duffy blood group system with U antigen ✓

Explanation

The Duffy blood group system, specifically the U antigen, is associated with an increased risk of hemolytic disease of the newborn (HDN) due to anti-U antibodies.

Source

National Institute of Health (NIH) research studies
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Hard MEDICAL Confidence: medium