Which of the following blood group antigens is known to be highly immunogenic and can cause severe hemolytic disease of the fetus and newborn?

A RhD antigen ✓
B Kell antigen
C Duffy antigen
D MNS antigen

Explanation

The RhD antigen is highly immunogenic and can cause severe hemolytic disease of the fetus and newborn if an RhD-negative mother is sensitized to RhD-positive blood.

Mnemonic

RhD = 'Danger' to fetus

Source

Williams Hematology
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Medium MEDICAL Confidence: high